The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein
Identifieur interne : 005A54 ( Main/Exploration ); précédent : 005A53; suivant : 005A55The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein
Auteurs : Martin Spiegel [Allemagne] ; Andreas Pichlmair [Allemagne] ; Elke Mühlberger [Allemagne] ; Otto Haller [Allemagne] ; Friedemann Weber [Allemagne]Source :
- Journal of clinical virology [ 1386-6532 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Protéines G.
- pharmacologie : Interféron bêta.
- physiologie : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Antiviral, Beta interferon, Chlorocebus aethiops, Coronavirus, GTP-Binding Proteins (metabolism), Humans, Interferon-beta (pharmacology), Microbiology, Myxovirus Resistance Proteins, Protein, SARS Virus (drug effects), SARS Virus (physiology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Vero Cells, Virology, Virus Replication (drug effects).
- MESH :
- chemical , metabolism : GTP-Binding Proteins.
- chemical , pharmacology : Interferon-beta.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Humans, Myxovirus Resistance Proteins, Vero Cells.
Abstract
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV. No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta. Nevertheless, no interference with SARS-CoV replication was observed in Vero cells stably expressing MxA. Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV.
Affiliations:
- Allemagne
- Bade-Wurtemberg, District de Fribourg-en-Brisgau, District de Giessen, Hesse (Land)
- Fribourg-en-Brisgau, Marbourg
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Le document en format XML
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last="Pichlmair">Andreas Pichlmair</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Abteilung Virologie, Institut für Medizinische Mikrobiologie und, Hygiene, Universität Freiburg</s1><s2>79008 Freiburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Muhlberger, Elke" sort="Muhlberger, Elke" uniqKey="Muhlberger E" first="Elke" last="Mühlberger">Elke Mühlberger</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institut für Virologie der Philipps-Universität Marhurg</s1><s2>35037 Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Haller, Otto" sort="Haller, Otto" uniqKey="Haller O" first="Otto" last="Haller">Otto Haller</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Abteilung Virologie, Institut für Medizinische Mikrobiologie und, Hygiene, Universität Freiburg</s1><s2>79008 Freiburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Abteilung Virologie, Institut für Medizinische Mikrobiologie und, Hygiene, Universität Freiburg</s1><s2>79008 Freiburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of clinical virology</title><title level="j" type="abbreviated">J. clin. virol.</title><idno type="ISSN">1386-6532</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of clinical virology</title><title level="j" type="abbreviated">J. clin. virol.</title><idno type="ISSN">1386-6532</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral</term><term>Beta interferon</term><term>Chlorocebus aethiops</term><term>Coronavirus</term><term>GTP-Binding Proteins (metabolism)</term><term>Humans</term><term>Interferon-beta (pharmacology)</term><term>Microbiology</term><term>Myxovirus Resistance Proteins</term><term>Protein</term><term>SARS Virus (drug effects)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Severe acute respiratory syndrome</term><term>Vero Cells</term><term>Virology</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Humains</term><term>Interféron bêta (pharmacologie)</term><term>Protéines G (métabolisme)</term><term>Protéines de résistance aux myxovirus</term><term>Réplication virale ()</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>GTP-Binding Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interferon-beta</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines G</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Interféron bêta</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Humans</term><term>Myxovirus Resistance Proteins</term><term>Vero Cells</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Coronavirus</term><term>Antiviral</term><term>Humains</term><term>Interféron bêta</term><term>Protéine</term><term>Microbiologie</term><term>Protéines de résistance aux myxovirus</term><term>Réplication virale</term><term>Virologie</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV. No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta. Nevertheless, no interference with SARS-CoV replication was observed in Vero cells stably expressing MxA. Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Fribourg-en-Brisgau</li><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Fribourg-en-Brisgau</li><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Spiegel, Martin" sort="Spiegel, Martin" uniqKey="Spiegel M" first="Martin" last="Spiegel">Martin Spiegel</name></region><name sortKey="Haller, Otto" sort="Haller, Otto" uniqKey="Haller O" first="Otto" last="Haller">Otto Haller</name><name sortKey="Muhlberger, Elke" sort="Muhlberger, Elke" uniqKey="Muhlberger E" first="Elke" last="Mühlberger">Elke Mühlberger</name><name sortKey="Pichlmair, Andreas" sort="Pichlmair, Andreas" uniqKey="Pichlmair A" first="Andreas" last="Pichlmair">Andreas Pichlmair</name><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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